Chaophraya Abhaibhubejhr Building was established in 1909 by Chaophraya Abhaibhubejhr (Chum Abhaiwong), built with the European Baroque architecture to be the reception palace for King Rama V, for his majesty should visit Prachinburi area; however, the king had passed away before. Subsequently, the building was used as the Royal Reception Hall for King Rama VI, along with other royal family. Nevertheless, the owner of this building had never used this building personally for all of his entire life.

     After Chaophraya Abhaibhubejhr had passed away, the building ownership was returned to Abhaiwong family, the ownership of building and surrounding lands were then inherited to Princess Suwandhana. While she went staying with her daughter in England, she bestowed all the property to The 2nd Army area, Prachinburi province to be a military hospital and for general public used. Consequently, the ownership was transferred to Ministry of Public Health, and was founded to be Prachinburi hospital, later its name was changed to Abhaibhubejhr hospital.

     Abhaibhubejhr Building was formerly an administrative building of the hospital, the first floor was adapt to be examination room, pharmacy, and operating room. The upper floor serves as female in-patients. The building had served as a hospital until the present administrative building was established in 1969. Abhaibhubejhr Building sometimes used for meeting and seminar, until the 1990 The Fine Arts Department  announced registration of Abhaibhubejhr Building as a national historic, and has been  awarded as the outstanding architecture building, from Her Royal Highness Princess Maha Chakri Sirindhorn.

     In 1994, the hospital then launched the project, Thai Herbal Medicine museum.  Aim to be research, study, references, and gathering Thai medicine reservation, Thai medicine, Local medicine. Moreover, there is knowledge management sharing more broadly, by support of Doctor Phairoj Ningsanit, former Minister of Public Health to establish Muen cham nan pat (Ploy Pattaya) foundation.

     The permanent exhibition was divided into 13 halls of;

1.     Introducing Abhaibhubejhr Traditional Thai Medicine

2.     History Hall

3.     Royal Reception Hall

4.     Thai Herbal Medicine Room

5.     History of Prachin Buri province

6.     Agarwood Room

7.     Royal Doctor Room (Muen Chamnan Pat)

8.     Medicinal Texts

9.     History of Abhaibhubejhr Herbal Medicine Development

10. History of Abhaibhubejhr hospital

11. Central Hall

12. Meeting Room

13. Multipurpose Room